World renowned physicist Stephen Hawking has died at the age of 76.
He died peacefully at his home in Cambridge in the early hours of Wednesday, his family said.
The British scientist was famed for his work with black holes and relativity, and wrote several popular science books including A Brief History of Time.
At the age of 22 Prof Hawking was given only a few years to live after being diagnosed with a rare form of motor neurone disease.
The illness left him in a wheelchair and largely unable to speak except through a voice synthesiser.
In a statement his children, Lucy, Robert and Tim, said: "We are deeply saddened that our beloved father passed away today.
"He was a great scientist and an extraordinary man whose work and legacy will live on for many years."
They praised his "courage and persistence" and said his "brilliance and humour" inspired people across the world.
"He once said, 'It would not be much of a universe if it wasn't home to the people you love.' We will miss him forever."
A book of condolence has been opened at Gonville and Caius College in Cambridge, where Prof Hawking was a fellow.
Prof Hawking was the first to set out a theory of cosmology as a union of relativity and quantum mechanics.
He also discovered that black holes leak energy and fade to nothing - a phenomenon that would later become known as Hawking radiation.
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Through his work with mathematician Sir Roger Penrose he demonstrated that Einstein's general theory of relativityimplies space and time would have a beginning in the Big Bang and an end in black holes.
The scientist gained popularity outside the academic world and appeared in several TV shows including The Simpsons, Red Dwarf and The Big Bang Theory.
Benedict Cumberbatch, who played Prof Hawking in a BBC drama, said he was "a true inspiration for me and for millions around the world".
BBC/PA
His most famous book - A Brief History of Time - has now shot to the top of the Amazon Best Sellers list.
The Motor Neurone Disease Association, of which Prof Hawking had been a patron since 2008, reported that its website had crashed because of an influx of donations to the charity.
Factfile: Stephen Hawking
- Born 8 January 1942 in Oxford, England
- Earned place at Oxford University to read natural science in 1959, before studying for his PhD at Cambridge
- By 1963, was diagnosed with motor neurone disease and given two years to live
- Outlined his theory that black holes emit "Hawking radiation" in 1974
- In 1979, he became the Lucasian Professor of Mathematics at Cambridge - a post once held by Sir Isaac Newton
- Published his book A Brief History of Time in 1988, which has sold more than 10 million copies
- In the late 1990s, he was reportedly offered a knighthood, but 10 years later revealed he had turned it down over issues with the government's funding for science
Tributes have poured in for Prof Hawking since the announcement of his death.
Prof Lord Martin Rees, the Astronomer Royal, who was at university with Prof Hawking when he was diagnosed, said his friend had "amazing willpower and determination".
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Prime Minister Theresa May called him a "brilliant and extraordinary mind" and "one of the great scientists of his generation".
Labour leader Jeremy Corbyn praised the scientist for his "determination to explain the mysteries of the cosmos" and his "burning passion to protect our National Health Service."
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